Genetic detection of lymph node micrometastases in patients with gastric carcinoma by multiple-marker reverse transcriptase-polymerase chain reaction assay.

@article{Okada2001GeneticDO,
  title={Genetic detection of lymph node micrometastases in patients with gastric carcinoma by multiple-marker reverse transcriptase-polymerase chain reaction assay.},
  author={Yousuke Okada and Yoshiyuki Fujiwara and Hiroshi Yamamoto and Yurika Sugita and Takushi Yasuda and Yuichiro Doki and Shigeyuki Tamura and Masahiko Yano and Hitoshi Shiozaki and Nariaki Matsuura and Morito Monden},
  journal={Cancer},
  year={2001},
  volume={92 8},
  pages={2056-64}
}
BACKGROUND Some patients with gastric carcinoma experience local disease recurrence despite undergoing curative resection of the tumor and regional lymph nodes (LNs), suggesting the presence of occult micrometastases. To evaluate the presence of gastric carcinoma micrometastasis in patients with otherwise histologically negative LNs, the authors established and tested a multiple-marker reverse transcriptase-polymerase chain reaction (RT-PCR) assay. METHODS The authors assessed 435 LNs from 28… CONTINUE READING
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