Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures

@article{Kaminski2005GeneticDO,
  title={Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures},
  author={R. Kaminski and T. Shippenberg and J. Witkin and B. Rocha},
  journal={Neuroscience Letters},
  year={2005},
  volume={382},
  pages={51-55}
}
Norepinephrine (NE) has been reported to modulate neuronal excitability and act as endogenous anticonvulsant. In the present study we used NE transporter knock-out mice (NET-KO), which are characterized by high levels of extracellular NE, to investigate the role of endogenous NE in seizure susceptibility. Seizure thresholds for cocaine (i.p.), pentylenetetrazol (i.v.) and kainic acid (i.v.) were compared in NET-KO, heterozygous (NET-HT) and wild type (NET-WT) female mice. The dose-response… Expand
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