Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

@article{Liliental2000GeneticDO,
  title={Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases},
  author={Joanna Liliental and Sun Young Moon and Ralf Lesche and Ramanaiah Mamillapalli and Daming Li and Yi cheng Zheng and Hong Sun and Hong Wu},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={401-404}
}
Pten (Phosphatase and tensin homolog deleted on chromosome 10) is a recently identified tumor suppressor gene which is deleted or mutated in a variety of primary human cancers and in three cancer predisposition syndromes [1]. Pten regulates apoptosis and cell cycle progression through its phosphatase activity on phosphatidylinositol (PI) 3,4,5-trisphosphate (PI(3,4,5)P(3)), a product of PI 3-kinase [2-5]. Pten has also been implicated in controlling cell migration [6], but the exact mechanism… CONTINUE READING
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