Genetic deletion of placenta growth factor in mice alters uterine NK cells.

@article{Tayade2007GeneticDO,
  title={Genetic deletion of placenta growth factor in mice alters uterine NK cells.},
  author={Chandrakant Tayade and David Hilchie and Hong He and Yuan Fang and Lieve Moons and Peter Carmeliet and Robert A. Foster and B Anne Croy},
  journal={Journal of immunology},
  year={2007},
  volume={178 7},
  pages={4267-75}
}
Placenta growth factor (PlGF; formerly PGF), a vascular endothelial growth factor gene family member, is expressed in human implantation sites by maternal uterine NK (uNK) and fetal trophoblast cells. Lower than normal concentrations of blood and urinary PlGF have been associated with impending onset of pre-eclampsia, a hypertensive disease of late human gestation characterized by limited intravascular trophoblast invasion. In pregnant rodents, delivery of the PlGF antagonist sFlt-1 or S… CONTINUE READING