Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

@article{Parsons2013GeneticDO,
  title={Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice},
  author={Michael James Parsons and Laura McCormick and Laura Janke and Adrienne N. Howard and Lisa Bouchier-Hayes and Douglas R Green},
  journal={Cell Death and Differentiation},
  year={2013},
  volume={20},
  pages={1174-1182}
}
Despite being the most evolutionarily conserved of the mammalian caspases, little is understood about the cellular function of caspase-2 in normal tissues or what role caspase-2 may have in the progression of human disease. It has been reported that deletion of the caspase-2 gene (Casp2), accelerates Eμ-myc lymphomagenesis in mice, and thus caspase-2 may act as a tumor suppressor in hematological malignancies. Here, we sought to extend these findings to epithelial cancers by examining the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…