Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.

@article{Guo2006GeneticDO,
  title={Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.},
  author={Fukun Guo and Marcella Debidda and Linda Yang and David A Williams and Yi cheng Zheng},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 27},
  pages={18652-9}
}
Rac1 is an intracellular signal transducer regulating a variety of cell functions. Previous studies by overexpression of dominant-negative or constitutively active mutants of Rac1 in clonal cell lines have established that Rac1 plays a key role in actin lamellipodia induction, cell-matrix adhesion, and cell anoikis. In the present studies, we have examined the cellular behaviors of Rac1 gene-targeted primary mouse embryonic fibroblasts (MEFs) after Cre recombinase-mediated deletion of Rac1 gene… CONTINUE READING

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