Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition.

@article{Cheng2001GeneticDO,
  title={Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition.},
  author={H F Cheng and J L Wang and Ming Zhang and Steven W. Wang and James A. McKanna and Raymond C Harris},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={280 3},
  pages={F449-56}
}
Cyclooxygenase-2 (COX-2) is expressed in macula densa (MD) and surrounding cortical thick ascending limb of the loop of Henle (cTALH) and is involved in regulation of renin production. We and others have previously found that selective COX-2 inhibitors can inhibit renal renin production (Cheng HF, Wang JL, Zhang MZ, Miyazaki Y, Ichikawa I, McKanna JA, and Harris RC. J Clin Invest 103: 953-961, 1999; Harding P, Sigmon DH, Alfie ME, Huang PL, Fishman MC, Beierwaltes WH, and Carretero OA… CONTINUE READING