Genetic deletion of CB1 receptors improves non-associative learning

@article{Degroot2005GeneticDO,
  title={Genetic deletion of CB1 receptors improves non-associative learning},
  author={A. Willem Degroot and Craig Richard Salhoff and Robert James Davis and George Goulielmos Nomikos},
  journal={Behavioural Brain Research},
  year={2005},
  volume={162},
  pages={161-164}
}
Habituation (a form of non-associative learning) was measured by assessing locomotion in novel activity monitors in CB1 receptor knockout mice and juxtaposed to habituation measured in muscarinic M2, M4, and double M2/M4 receptor knockout mice. M2 and M2/M4, but not M4, receptor knockout mice appeared to have an impaired ability to habituate, whereas CB1 receptor knockout mice showed enhanced habituation compared to wild-type animals. We conclude that CB1 receptor gene invalidation improves… CONTINUE READING
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