Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.

@article{Brhler2009GeneticDO,
  title={Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension.},
  author={Sebastian Br{\"a}hler and Anuradha Kaistha and Volker J Schmidt and Stephanie E. W{\"o}lfle and Christoph Busch and Brajesh Pratap Kaistha and Michael Kacik and Anna-Lena Hasenau and Ivica Grgic and Han Si and Chris T. Bond and John P Adelman and Heike Wulff and Cor de Wit and Joachim Hoyer and Ralf K{\"o}hler},
  journal={Circulation},
  year={2009},
  volume={119 17},
  pages={2323-32}
}
BACKGROUND It has been proposed that activation of endothelial SK3 (K(Ca)2.3) and IK1 (K(Ca)3.1) K+ channels plays a role in the arteriolar dilation attributed to an endothelium-derived hyperpolarizing factor (EDHF). However, our understanding of the precise function of SK3 and IK1 in the EDHF dilator response and in blood pressure control remains incomplete. To clarify the roles of SK3 and IK1 channels in the EDHF dilator response and their contribution to blood pressure control in vivo, we… CONTINUE READING