Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.

@article{Koshy2010GeneticDO,
  title={Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.},
  author={Beena Koshy and Akinori Miyashita and Pamela St. Jean and Heide A. Stirnadel and Toshihiko Kaise and Justin P. Rubio and Vincent Mooser and Ryozo Kuwano and Michael C. Irizarry},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={21 3},
  pages={775-80}
}
High plasma lipoprotein phospholipase A2 activity (Lp-PLA2) is reported to be a risk factor for dementia. A loss of function polymorphism in the Lp-PLA2 gene - PLA2G7 V279F - is found almost exclusively in Asians. In 1,952 subjects with late-onset AD and 2,079 non-demented controls recruited from Japan, the PLA2G7 null allele was not associated with risk or… CONTINUE READING