Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice.

@article{Gitlin2007GeneticDO,
  title={Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice.},
  author={Jonathan M. Gitlin and Darshini B. Trivedi and Robert I Langenbach and Charles D. Loftin},
  journal={Cardiovascular research},
  year={2007},
  volume={73 1},
  pages={227-36}
}
OBJECTIVE Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammation which contributes to the remodeling and eventual weakening of the vessel wall. Increased cyclooxygenase-2 (COX-2) expression is detected in human aneurysmal tissue and is suggested to contribute to the disease. The aim of the current study was to define the role of COX-2 expression in the development of AAAs, using a model of the disease. METHODS AAAs were induced in mice by chronic angiotensin II infusion… CONTINUE READING