Genetic deficiency in Pparg does not alter development of experimental prostate cancer

@article{Saez2003GeneticDI,
  title={Genetic deficiency in Pparg does not alter development of experimental prostate cancer},
  author={Enrique Saez and Peter Olson and Ronald M Evans},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={1265-1266}
}
The role of the nuclear peroxisome proliferator–activated receptor (PPAR)-γ in cancer has been a subject of debate. The identification of loss-of-function mutations in PPARG in colon and prostate tumors has led to the idea that this gene may function as a tumor suppressor. We have directly tested this notion using a mouse model of prostate cancer. Neither hemizygous deletion of Pparg nor complete ablation of Ppara influenced the development of prostate cancer in our experimental context. 

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NATURE MEDICINE Table 1 Kinetics of tumor development in TRAMP mice with reduced PPAR gene dosage Genotype n Incidence Days to death TRAMP 20 100% 250 TRAMP Ppara+/– 12 100% 244* TRAMP Ppara–/

Collett, G.P
Clin. Cancer Res • 2000