Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism.

@article{Mahley1991GeneticDI,
  title={Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism.},
  author={Robert W. Mahley and Karl H. Weisgraber and Thomas L. Innerarity and Stanley C. Rall},
  journal={JAMA},
  year={1991},
  volume={265 1},
  pages={78-83}
}
Certain proteins (called apolipoproteins B and E) on the surface of lipoprotein particles are responsible for mediating the binding of cholesterol-rich particles to specific lipoprotein receptors on the surface of cells and represent a major pathway controlling blood cholesterol levels. Three important disorders of lipoprotein metabolism, which provide insights into the molecular mechanisms responsible for the elevation of specific atherogenic lipoproteins, are the following: (1) Type III… CONTINUE READING

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