Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.

@article{Nomura2000GeneticDI,
  title={Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.},
  author={Keiko Nomura and Hirokazu Kanegane and Hajime Karasuyama and Satoshi Tsukada and Kazunaga Agematsu and Gyo Murakami and Satoru Sakazume and Masahiro Sako and Ryuhei Tanaka and Yoshinori Kuniya and Takuya Komeno and Sonoko Ishihara and Katsuhiko Hayashi and Tomoko Kishimoto and Toshio Miyawaki},
  journal={Blood},
  year={2000},
  volume={96 2},
  pages={610-7}
}
Surrogate light chains (lambda 5/VpreB) are selectively expressed in early precursors of B cells. B-cell defects in X-linked agammaglobulinemia (XLA) are caused by mutations in the gene for Bruton's tyrosine kinase. To elucidate the nature of early B-lineage cells in bone marrow (BM), samples from 13 XLA patients and 24 healthy controls of different ages were comparatively analyzed using an antihuman VpreB monoclonal antibody. Expression of surrogate light (SL) and mu-heavy chains were examined… CONTINUE READING

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Atypical X-linked agammaglobulinemia (XLA) diagnosed in adult

  • S Hashimoto, T Miyawaki, T Futatani
  • Internal Med
  • 1999

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