Genetic damage in oligozoospermic patients detected by fluorescence in-situ hybridization, inverse restriction site mutation assay, sperm chromatin structure assay and the Comet assay.

@article{Schmid2003GeneticDI,
  title={Genetic damage in oligozoospermic patients detected by fluorescence in-situ hybridization, inverse restriction site mutation assay, sperm chromatin structure assay and the Comet assay.},
  author={Thomas Ernst Schmid and Axel Kamischke and Hildegard Bollwein and Eberhard Nieschlag and Martin H Brinkworth},
  journal={Human reproduction},
  year={2003},
  volume={18 7},
  pages={1474-80}
}
BACKGROUND The possibility that oligozoospermic men may have elevated levels of genetic damage in their sperm is of particular concern as they could transmit defects to their offspring. METHODS Sperm samples were obtained from 12 infertile, oligozoospermic patients and 12 healthy normozoospermic volunteers. Fluorescence in-situ hybridization (FISH) was used to determine aneuploidy rates in sperm and inverse restriction site mutation (iRSM) assay to determine gene mutations; defective… CONTINUE READING

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