Genetic damage in chronic renal failure patients is associated with the glomerular filtration rate index.

@article{Sandoval2010GeneticDI,
  title={Genetic damage in chronic renal failure patients is associated with the glomerular filtration rate index.},
  author={Silvia Berenice Sandoval and Elitsa Stoyanova and Elisabet Coll and Susana Pastor and Joselyn Reyes and Enrique de Andres and J M Sistac Ballar{\'i}n and Noel Xamena and Ricard Marcos},
  journal={Mutagenesis},
  year={2010},
  volume={25 6},
  pages={603-8}
}
Chronic renal failure (CRF) patients are considered to present genomic instability and, as a consequence, elevated levels of genetic damage. An open question is whether this damage is related to the stage of the pathology. To determine the background levels of genetic damage, a large population of 258 Caucasian adults (201 CRF patients and 57 controls) was analysed using the micronucleus (MN) assay. The frequency of MN in CRF patients was significantly higher than in controls and correlated… CONTINUE READING