Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress.

@article{PiaGuzmn2006GeneticDC,
  title={Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress.},
  author={Belem Pi{\~n}a-Guzm{\'a}n and Mar{\'i}a de Jes{\'u}s Sol{\'i}s-Heredia and Aurora Elizabeth Rojas-Garc{\'i}a and Mayrut Uri{\'o}stegui-Acosta and Betzabet Quintanilla-Vega},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={216 2},
  pages={216-24}
}
Organophosphorous (OP) pesticides are considered genotoxic mainly to somatic cells, but results are not conclusive. Few studies have reported OP alterations on sperm chromatin and DNA, and oxidative stress has been related to their toxicity. Sperm cells are very sensitive to oxidative damage which has been associated with reproductive dysfunctions. We evaluated the effects of methyl-parathion (Me-Pa; a widely used OP) on sperm DNA, exploring the sensitive stage(s) of spermatogenesis and the… CONTINUE READING