Genetic controls for the expression of surface antigens in African trypanosomes.

@article{Pays1994GeneticCF,
  title={Genetic controls for the expression of surface antigens in African trypanosomes.},
  author={E. Pays and Luc Vanhamme and Magali Berberof},
  journal={Annual review of microbiology},
  year={1994},
  volume={48},
  pages={25-52}
}
The major surface antigens of African trypanosomes, variant surface glycoprotein (VSG) and procyclin, are typical markers of their respective developmental stages, the bloodstream form and the insect-specific procyclic form. Although the role of procyclin is still unclear, variation of the VSG in the blood allows the parasite to escape the immune response of the host and develop a chronic infection. In this review, we discuss the available information concerning the genetic mechanisms that… CONTINUE READING