Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants.

@article{Raschke1973GeneticCO,
  title={Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants.},
  author={William C. Raschke and Kenneth A. Kern and C Antalis and Clinton E. Ballou},
  journal={The Journal of biological chemistry},
  year={1973},
  volume={248 13},
  pages={4660-6}
}
The yeast Saccharomyces cerevisiae X2180, the strain most commonly used for genetic studies on yeasts, was treated with the mutagen ethyl methanesulfonate, and mutants defective in the synthesis of cell wall mannan were isolated. The initial selection of mutants was made on the basis of their failure to agglutinate with antiserum that was specific for the mannotetraose side chain of the mannan, the immunodominant group of this yeast strain, which has the structure crMan(l-+3)otMan(l+Z)aMan(l-t2… CONTINUE READING
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