Genetic control of the response of chicken T lymphocytes to concanavalin A: cellular localization of the low responder defect.


Genetic variation in the response of chicken lymphocytes to the T cell mitogen concanavalin A (Con A) has previously been studied by assaying tritiated thymidine [( 3H]dThd) uptake of cultured cells following mitogen stimulation. Our present results show, firstly, that low [3H]dThd uptake (e.g. in cultures of Con A-stimulated cells from low responder CB, CC… (More)