Genetic control of programmed cell death (apoptosis) in Drosophila.


Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.

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@article{Xu2009GeneticCO, title={Genetic control of programmed cell death (apoptosis) in Drosophila.}, author={Dongbin Xu and Sarah E. Woodfield and Tom V. Lee and Yunliu Fan and Christian Antonio and Andreas Bergmann}, journal={Fly}, year={2009}, volume={3 1}, pages={78-90} }