Genetic control of ocular morphogenesis: defective lens development associated with ocular anomalies in C57BL/6 mice.

@article{Robinson1993GeneticCO,
  title={Genetic control of ocular morphogenesis: defective lens development associated with ocular anomalies in C57BL/6 mice.},
  author={M. L. Robinson and Arne Holmgren and M. J. Dewey},
  journal={Experimental eye research},
  year={1993},
  volume={56 1},
  pages={7-16}
}
Congenital ocular defects, including microphthalmia, anophthalmia and cataracts appear in a small proportion (5-15%) of the C57BL/6 inbred strain of laboratory mice. Previous work from this laboratory utilizing C57BL/6 in equilibrium with DBA/2 allophenic (mosaic) mice suggested that the underlying cause of these defects may be a deficiency in C57BL/6 lens development. In these C57BL/6 in equilibrium with DBA/2 allophenic animals, the major proportion of the lens cells were of the DBA/2 strain… CONTINUE READING

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