Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.

@article{Gros1981GeneticCO,
  title={Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.},
  author={Philippe Gros and Emil Skamene and Adrien Forget},
  journal={Journal of immunology},
  year={1981},
  volume={127 6},
  pages={
          2417-21
        }
}
Mice of 12 inbred strains infected i.v. with Mycobacterium bovis (BCG) exhibited 2 distinct patterns of response as determined by the degree of BCG burden in the spleens of animals at 3 wk after infection with 10(4) viable bacilli: susceptible (C57BL/6J and related sublines, BALB/c and DBA/1J) and resistant (A/J, C3H/HeCr, DBA/2J, CBA/J, C57Br, AKR). Mendelian analysis of this trait on segregating backcross and F2 populations derived from the mating of resistant and susceptible progenitors was… CONTINUE READING

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