Genetic control of multiple sclerosis: increased production of lymphotoxin and tumor necrosis factor-alpha by HLA-DR2+ T cells.

@article{Zipp1995GeneticCO,
  title={Genetic control of multiple sclerosis: increased production of lymphotoxin and tumor necrosis factor-alpha by HLA-DR2+ T cells.},
  author={Frauke Zipp and Frank S Weber and Sally Huber and Stefano Sotgiu and Anna Czlonkowska and Ernst Holler and Ekkehard Albert and Elisabeth H. Weiss and Hartmut Wekerle and Reinhard Hohlfeld},
  journal={Annals of neurology},
  year={1995},
  volume={38 5},
  pages={723-30}
}
Lymphotoxin (LT) and tumor necrosis factor-alpha (TNF-alpha) play an important role in the pathogenesis of multiple sclerosis (MS). MS is associated with the HLA-DR2, Dw2, DQ6 HLA class II haplotype. Because both LT and TNF-alpha are encoded in the HLA region, the HLA association of MS may be related to the production of these cytokines. To test this hypothesis, we investigated the production of LT, TNF-alpha, and interferon-gamma (IFN-gamma) by CD4+ T-cell lines (TCLs) specific for myelin… CONTINUE READING

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