Genetic control of malaria parasite transmission: threshold levels for infection in an avian model system.

@article{Jasinskiene2007GeneticCO,
  title={Genetic control of malaria parasite transmission: threshold levels for infection in an avian model system.},
  author={Nijole Jasinskiene and Judy L. Coleman and Aurora Ashikyan and Michael Salampessy and Osvaldo Marinotti and Anthony A. James},
  journal={The American journal of tropical medicine and hygiene},
  year={2007},
  volume={76 6},
  pages={1072-8}
}
Genetic strategies for controlling malaria transmission based on engineering pathogen resistance in Anopheles mosquitoes are being tested in a number of animal models. A key component is the effector molecule and the efficiency with which it reduces parasite transmission. Single-chain antibodies (scFvs) that bind the circumsporozoite protein of the avian parasite, Plasmodium gallinaceum, can reduce mean intensities of sporozoite infection of salivary glands by two to four orders of magnitude in… CONTINUE READING

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