Genetic control of macrophage susceptibility to infection by Legionella pneumophila.

@article{Yamamoto1992GeneticCO,
  title={Genetic control of macrophage susceptibility to infection by Legionella pneumophila.},
  author={Yoshimasa Yamamoto and Thomas W. Klein and Howard M. Friedman},
  journal={FEMS microbiology immunology},
  year={1992},
  volume={4 3},
  pages={
          137-45
        }
}
Legionella pneumophila readily grows in cultures of thioglycollate (TGC)-induced macrophages (MPs) from A/J mice, but not in MPs from BALB/c mice or other mouse strains. In the present study, the growth of Legionella pneumophilia in MPs from A/J and BALB/c mice, as well as hybrids of the two strains and back-crossed mice, was investigated to determine whether the permissiveness of growth of these bacteria was due to an inherited trait of the MPs. The MPs from all A/J mice supported the growth… CONTINUE READING
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