Genetic control of longevity in C. elegans

@article{Braeckman2007GeneticCO,
  title={Genetic control of longevity in C. elegans
},
  author={B. Braeckman and J. Vanfleteren},
  journal={Experimental Gerontology},
  year={2007},
  volume={42},
  pages={90-98}
}
The nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity. Over 70 genes have been found to influence lifespan in this worm. Those related to the Ins/IGF signaling pathway are among the best studied and will be focused on in this review. The master regulator of this pathway, the forkhead transcription factor DAF-16, can activate an enhanced life maintenance program in response to environmental and gonadal inputs. DAF-16 up- and downregulates… Expand
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