Genetic control of immunity to Plasmodium yoelii sporozoites.

  title={Genetic control of immunity to Plasmodium yoelii sporozoites.},
  author={Walter R. Weiss and Michael F Good and Michael R Hollingdale and Louis H. Miller and Jay A Berzofsky},
  journal={Journal of immunology},
  volume={143 12},
Using a rodent malaria system, we have shown that protective immunity to the preerythrocytic stages of malaria is genetically controlled by MHC and non-MHC genes. Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals that did not develop blood stage infections. Immunity did not correlate with antisporozoite antibody levels. Two protective mechanisms exist determined… CONTINUE READING