Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes.

@article{Brown2001GeneticCO,
  title={Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes.},
  author={Matthew A Brown and Michael A. Haughton and Struan Frederick Airth Grant and Anthony S Gunnell and Neil J. K. Henderson and John A. Eisman},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 4},
  pages={
          758-64
        }
}
Genetic factors are known to influence both the peak bone mass and probably the rate of change in bone density. A range of regulatory and structural genes has been proposed to be involved including collagen 1alpha (COL1A1), the estrogen receptor (ER), and the vitamin D receptor (VDR), but the actual genes involved are uncertain. We therefore studied the role of the COL1A1 and VDR loci in control of bone density by linkage in 45 dizygotic twin pairs and 29 nuclear families comprising 120… CONTINUE READING
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