Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats

@article{VingsboLundberg1998GeneticCO,
  title={Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats},
  author={Carina Vingsbo-Lundberg and Niklas Nordquist and Peter Olofsson and Mats Sundvall and Tore Saxne and U. Pettersson and Rikard Holmdahl.},
  journal={Nature Genetics},
  year={1998},
  volume={20},
  pages={401-404}
}
Rheumatoid arthritis (RA) is a chronic and genetically complex inflammatory disorder that leads to erosive destruction of peripheral joints. The use of animal models mimicking RA, such as pristane-induced arthritis (PIA) in rats, should facilitate its genetic analysis. Pristane is a non-immunogenic synthetic oil that, after a single subcutaneous injection into DA rats, induces arthritis restricted to peripheral joints with a chronic relapsing disease course. To identify genes involved in the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Genetic analysis of murine models for rheumatoid arthritis. in Human Genome Methods (ed. Adolpho, K.W.) 215–238

  • R Holmdahl
  • (CRC press,
  • 1998

a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes

  • Vingsbo, C. et al. Pristane-induced arthritis in rats
  • Am. J. Pathol. 149, 1675–1683
  • 1996

guidelines for interpreting and reporting linkage results

  • E. S. Lander, Kruglyak, L. Genetic dissection of complex traits
  • Nature Genet. 11, 241–247
  • 1996

Similar Papers

Loading similar papers…