Genetic control of Yarrowia lipolytica fatty acid synthetase biosynthesis and function.

@article{Schweizer1988GeneticCO,
  title={Genetic control of Yarrowia lipolytica fatty acid synthetase biosynthesis and function.},
  author={Eckhart Schweizer and Hartmut K{\"o}ttig and R Regler and Gerhard Rottner},
  journal={Journal of basic microbiology},
  year={1988},
  volume={28 5},
  pages={283-92}
}
Yarrowia lipolytica, like other lower fungi, has a fatty acid synthetase complex (FAS) with an alpha 6 beta 6 molecular structure. Both subunits are multifunctional proteins each with a molecular weight of more then 200,000 daltons. A collection of FAS-deficient) Y. lipolytica mutants was isolated and characterized by both genetic complementation and enzyme activity measurements. It was found that the three acyl transferases (acetyl-, malonyl- and palmityl-transacylation) together with the… CONTINUE READING