Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval.

@article{Chadwick2006GeneticCO,
  title={Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval.},
  author={Lisa H. Chadwick and Lisa M Pertz and Karl W. Broman and Marisa S Bartolomei and Huntington F. Willard},
  journal={Genetics},
  year={2006},
  volume={173 4},
  pages={
          2103-10
        }
}
In early mammalian development, one of the two X chromosomes is silenced in each female cell as a result of X chromosome inactivation, the mammalian dosage compensation mechanism. In the mouse epiblast, the choice of which chromosome is inactivated is essentially random, but can be biased by alleles at the X-linked X controlling element (Xce). Although this locus was first described nearly four decades ago, the identity and precise genomic localization of Xce remains elusive. Within the X… CONTINUE READING
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