Genetic contribution of the leukotriene pathway to coronary artery disease

@inproceedings{Hartiala2011GeneticCO,
  title={Genetic contribution of the leukotriene pathway to coronary artery disease},
  author={Jaana A. Hartiala and Dalin Li and David V. Conti and Susanna Vikman and Yesha M. Patel and W. H. Wilson Tang and Marie-Louise Brennan and John W. Newman and Charles Bolt Stephensen and Patrice Armstrong and Stanley L. Hazen and Hooman Allayee},
  booktitle={Human Genetics},
  year={2011}
}
We evaluated the genetic contribution of the leukotriene (LT) pathway to risk of coronary artery disease (CAD) in 4,512 Caucasian and African American subjects ascertained through elective cardiac evaluation. Of the three previously associated variants, the shorter “3” and “4” alleles of a promoter repeat polymorphism in ALOX5 increased risk of CAD in African Americans (OR = 1.4, 95% CI 1.0–1.9; p = 0.04), whereas a haplotype of LTA4H (HapK) was associated with CAD in Caucasians (OR = 1.2, 95… CONTINUE READING