Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2.

Abstract

Calcineurin a calmodulin-dependent phosphatase plays a critical role in calcium-dependent activation of T-lymphocytes and is the major target for the inhibitory actions of the immunosuppressive drugs Tacrolimus (FK506) and Cyclosporin A (CsA). Calcineurin is a dimeric protein consisting of distinct A (catalytic) and B (regulatory) subunits. In humans two… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.