Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA.

@article{Miesfeld1986GeneticCO,
  title={Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA.},
  author={R. Miesfeld and Sandro Rusconi and Paul J. Godowski and B A Maler and Sam Okret and A C Wikstr{\"o}m and J A Gustafsson and Keith R. Yamamoto},
  journal={Cell},
  year={1986},
  volume={46 3},
  pages={389-99}
}
We isolated and sequenced 6.3 kb of cDNA encoding that rat glucocorticoid receptor, a protein that binds and activates a class of hormone-dependent transcriptional enhancers. Receptor-containing cells produce receptor mRNAs of approximately equal to 6.5 kb and approximately equal to 4.8 kb that differ only in their 3' nontranslated regions; an open reading frame of 795 amino acids resides within the 5' portion of the transcripts. The coding region was expressed in vitro, in transient… CONTINUE READING

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