Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant.

@article{Wakasugi1998GeneticCI,
  title={Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant.},
  author={Kei Wakasugi and Cheryl L. Quinn and N Tao and Paul R. Schimmel},
  journal={The EMBO journal},
  year={1998},
  volume={17 1},
  pages={297-305}
}
The genetic code is established in aminoacylation reactions whereby amino acids are joined to tRNAs bearing the anticodons of the genetic code. Paradoxically, while the code is universal there are many examples of species-specific aminoacylations, where a tRNA from one taxonomic domain cannot be acylated by a synthetase from another. Here we consider an example where a human, but not a bacterial, tRNA synthetase charges its cognate eukaryotic tRNA and where the bacterial, but not the human… CONTINUE READING

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