Genetic clonal diversity predicts progression to esophageal adenocarcinoma

  title={Genetic clonal diversity predicts progression to esophageal adenocarcinoma},
  author={Carlo C. Maley and Patricia C. Galipeau and Jennifer C. Finley and Vaew J Wongsurawat and Xiaohong Li and Carissa A. Sanchez and Thomas G. Paulson and Patricia L. Blount and Rosa-ana Risques and Peter S. Rabinovitch and Brian J. Reid},
  journal={Nature Genetics},
Neoplasms are thought to progress to cancer through genetic instability generating cellular diversity and clonal expansions driven by selection for mutations in cancer genes. Despite advances in the study of molecular biology of cancer genes, relatively little is known about evolutionary mechanisms that drive neoplastic progression. It is unknown, for example, which may be more predictive of future progression of a neoplasm: genetic homogenization of the neoplasm, possibly caused by a clonal… CONTINUE READING
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