Genetic characterization to improve interpretation and clinical management of hepatotoxicity caused by tyrosine kinase inhibitors.

@article{Spraggs2013GeneticCT,
  title={Genetic characterization to improve interpretation and clinical management of hepatotoxicity caused by tyrosine kinase inhibitors.},
  author={Colin F. Spraggs and Chun-Fang Xu and C M Hunt},
  journal={Pharmacogenomics},
  year={2013},
  volume={14 5},
  pages={
          541-54
        }
}
  • Colin F. Spraggs, Chun-Fang Xu, C M Hunt
  • Published in Pharmacogenomics 2013
  • Biology, Medicine
  • Tyrosine kinase inhibitors (TKIs) represent important therapeutic alternatives to, or combinations with, traditional cytotoxic chemotherapy. Despite their selective molecular targeting and demonstrated clinical benefit, TKIs produce a range of serious adverse events, including drug-induced liver injury, that require careful patient management to maintain treatment benefit without harm. Genetic characterization of serious adverse events can identify mechanisms of injury and improve safety risk… CONTINUE READING

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