Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis.

@article{McKessar2000GeneticCO,
  title={Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis.},
  author={S J McKessar and Anne M. Berry and Jan M. Bell and John D. Turnidge and James C Paton},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 11},
  pages={3224-8}
}
Enterococcus faecalis strain WCH9 displays a moderate level of resistance to vancomycin (MIC = 16 microgram/ml) and full susceptibility to teicoplanin but is negative by PCR analysis using primers specific for all known enterococcal vancomycin resistance genotypes (vanA, vanB, vanC, vanD, and vanE). We have isolated and sequenced a novel putative vancomycin resistance locus (designated vanG), which contains seven open reading frames, from this strain. These are organized differently from those… CONTINUE READING

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