Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy.

@article{Grard2007GeneticCO,
  title={Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy.},
  author={Gilda Grard and Gr{\'e}gory Moureau and Remi N. Charrel and J J Lemasson and Jean Paul Gonzalez and Pierre Gallian and Tamara S. Gritsun and Edward C. Holmes and Ernest Andrew Gould and Xavier de Lamballerie},
  journal={Virology},
  year={2007},
  volume={361 1},
  pages={
          80-92
        }
}
Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi… Expand
Genomics and evolution of Aedes-borne flaviviruses.
TLDR
Viral evolution was found to be associated with the appearance of new biological characteristics; mutations that may modify the envelope protein structure were identified for seven viruses within the YFV group, and an expansion of host-vector range was identified in the two major evolutionary lineages, which in turn may facilitate the emergence of mosquito-borne flaviviruses. Expand
Molecular-based identification and phylogeny of genomic and proteomic sequences of mosquito-borne flavivirus
TLDR
In this study, complete genome, translated polyprotein, structural and non-structural proteins of MBFVs have been targeted and revealed an extensive series of clades defined by their epidemiology and disease associations. Expand
Short Communication Genomics and evolution of Aedes-borne flaviviruses
TLDR
Viral evolution was found to be associated with the appearance of new biological characteristics; mutations that may modify the envelope protein structure were identified for seven viruses within the YFV group, and an expansion of host–vectorrange was identified in the two major evolutionary lineages, which in turn may facilitate theergence of mosquito-borne flaviviruses. Expand
Louping ill virus: an endemic tick-borne disease of Great Britain.
TLDR
An overview of LIV is provided and areas where further effort is needed to control this disease are highlighted, particularly those whose occupation involves contact with sheep. Expand
Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
TLDR
An overview of MBFV-related viruses concludes that they differ from the ISFs genetically and antigenically, and provide new information on the variety, properties and evolution of vector-borne flaviviruses. Expand
Tick-borne encephalitis.
  • L. Lindquist
  • Biology, Medicine
  • Handbook of clinical neurology
  • 2014
TLDR
Animal experimental studies have elucidated the importance of CD8 + T cells in neuronal degradation in TBE and the role of Toll-like receptor 3 in the signaling pathway of TBEV–host interaction, which may open future possibilities for treatment of this devastating disease. Expand
Viruses transmitted by ticks.
TLDR
This chapter first considers the characteristics of ticks important in virus transmission and then presents an overview of the tick-borne members of different virus families. Expand
Identification and characterization of a novel tick-borne flavivirus subtype in goats (Capra hircus) in Spain.
TLDR
Empirical data demonstrates that the LIV-like virus detected is significantly divergent from LIV and Spanish sheep encephalitis virus (SSEV), and this virus encoded an amino acid sequence motif at the site of a previously identified marker for differentiating tick-borne flaviviruses. Expand
Detection of antibodies against tick-borne encephalitis flaviviruses in breeding and sport horses from Spain.
TLDR
The results demonstrate for the first time the presence of antibodies against TBE flaviviruses in horses residing in mainland Spain; further epidemiological surveys are necessary in order to understand and monitor the active transmission of TBE flavourings in this country. Expand
Tick-borne viruses: a review from the perspective of therapeutic approaches.
TLDR
The lack of treatment and prevention approaches for these viruses is highlighted, and it is hoped that this review may increase public health awareness with regard to the threat posed by this group of viruses. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 49 REFERENCES
Analysis of the complete genome of the tick-borne flavivirus Omsk hemorrhagic fever virus.
TLDR
Genetic classification and phylogenetic analysis demonstrated that OHF virus falls within the tick-borne encephalitis serocomplex of flaviviruses, yet is distinct from other members of the complex, including those closely associated geographically. Expand
Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography.
TLDR
Phylogenetic analysis of the Flavivirus genus revealed an extensive series of clades defined by their epidemiology and disease associations, which revealed distinct geographical clusters in either the Old World or the New World, which for mosquito-borne viruses may reflect an Old World origin. Expand
Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses.
TLDR
Comparisons among tick-borne and mosquito-borne flaviviruses revealed conserved sequence elements that might represent important determinants of the tick- borne flavivirus phenotype and emphasized structural elements that are conserved among both vector groups. Expand
Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia.
TLDR
Analysis of structural genes, genetic distances, and evolutionary relationship indicate that ALKV and KFDV derived from a common phylogenetic ancestor and constitute two genetic subtypes of the same virus species according to current genetic criteria of classification. Expand
Classification of a new member of the TBE flavivirus subgroup by its immunological, pathogenetic and molecular characteristics: identification of subgroup-specific pentapeptides.
TLDR
Molecular homology data of all the structural genes of TSE virus compared with other tick-borne flaviviruses demonstrated that TSEirus is a distinct member in the TBE virus subgroup, consistent with the conclusion that T SE virus has evolved by a separate evolutionary pathway as compared with the close antigenic relatives, western European, far eastern TBE viruses and LI virus. Expand
Genomic sequencing of deer tick virus and phylogeny of powassan-related viruses of North America.
TLDR
The lineage of DT virus is classified as a distinct genotype of POW virus, one of which had the prototype POW virus and the other DT virus, both of which can cause central nervous system infection in humans. Expand
Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia.
TLDR
The data presented in this study show that the 3'NCR is uniform among TBE viruses isolated from Siberia and far-eastern Asia and that the3' NCR is essential for TBE virus growth in tick and/or rodent host cells. Expand
Analysis of the structural protein gene sequence shows Kyasanur Forest disease virus as a distinct member in the tick-borne encephalitis virus serocomplex.
TLDR
KFD virus is a distinct member in the tick-borne flavivirus complex with characteristic protease cleavage sites, fusion peptide, signal sequences and hydrophobic transmembrane domains, and the possibility of developing recombinant virus vaccines is discussed. Expand
The virus causing encephalomyelitis in sheep in Spain: a new member of the tick-borne encephalitis group.
TLDR
It is concluded that the cause of sheep encephalomyelitis in Spain is a distinct species in the tick-borne encephalitis virus group. Expand
Nucleotide sequencing and serological evidence that the recently recognized deer tick virus is a genotype of Powassan virus.
TLDR
Nucleotide sequencing revealed a high degree of homology between DTV and POW at both nucleotide and amino acid levels, and the two viruses were indistinguishable in serological assays and mouse neuroinvasiveness. Expand
...
1
2
3
4
5
...