Genetic characterization of the dihydrofolate reductase gene of Pneumocystis jirovecii isolates from Portugal.

@article{Costa2006GeneticCO,
  title={Genetic characterization of the dihydrofolate reductase gene of Pneumocystis jirovecii isolates from Portugal.},
  author={Marina C Costa and Francisco Esteves and Francisco Ant{\'u}nes and O. Martı́nez Matos},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={58 6},
  pages={1246-9}
}
OBJECTIVES The aim of the present study was to evaluate the genetic variation of Pneumocystis jirovecii dihydrofolate reductase (DHFR) gene in an immunocompromised Portuguese population and to investigate the possible association between DHFR genotypes and P. jirovecii pneumonia (PcP) prophylaxis with co-trimoxazole. METHODS One hundred and thirty-eight P. jirovecii isolates were submitted to DHFR genetic characterization by PCR and sequencing. RESULTS In the studied population, 72.7% of… CONTINUE READING

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