Genetic characterization of frameshift suppressors with new decoding properties.

  title={Genetic characterization of frameshift suppressors with new decoding properties.},
  author={David Hughes and Suzanne Thompson and Michael H. O'Connor and T. M. Tuohy and Brian P Nichols and John F. Atkins},
  journal={Journal of bacteriology},
  volume={171 2},
Suppressor mutants that cause ribosomes to shift reading frame at specific and new sequences are described. Suppressors for trpE91, the only known suppressible -1 frameshift mutant, have been isolated in Escherichia coli and in Salmonella typhimurium. E. coli hopR acts on trpE91 within the 9-base-pair sequence GGA GUG UGA, is dominant, and is located at min 52 on the chromosome. Its Salmonella homolog maps at an equivalent position and arises as a rarer class in that organism as compared with E… CONTINUE READING


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