Genetic characterization of complex inter-recombinant HIV-1 strains circulating in Spain and reliability of distinct rapid subtyping tools.

@article{Holgun2008GeneticCO,
  title={Genetic characterization of complex inter-recombinant HIV-1 strains circulating in Spain and reliability of distinct rapid subtyping tools.},
  author={{\'A}frica Holgu{\'i}n and Eva Lospitao and Marisa L{\'o}pez and Eva Ram{\'i}rez de Arellano and Maria Jos{\'e} Mellado Pena and Jorge del Romero and Cristina V{\'a}zquez Mart{\'i}n and Vicente Soriano},
  journal={Journal of medical virology},
  year={2008},
  volume={80 3},
  pages={383-91}
}
Genetic recombination and high rate of mutation increase HIV-1 diversity, allowing viruses to escape more easily from the host immune response or antiretroviral drugs. The recombinant nature of full-length HIV-1 genomic sequences derived from viruses infecting five epidemiologically unlinked individuals carrying HIV-1 non-B variants was investigated. Overlapping PCR amplifications followed by direct sequencing of viral products derived from plasma and phylogenetic analyses were carried out… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…