Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor.

Abstract

The nucleotide sequence of the structural gene for filamentous haemagglutinin (FHA), fhaB, a crucial adherence factor for Bordetella pertussis, has been determined. Its 10774 nucleotides are far more than necessary to encode the 220 kD biologically active, mature polypeptide product, suggesting a role for co- or post-translational processing. Fusion… (More)

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