Genetic characterization and phylogenetic analysis of HIV-1 subtype C from Uganda.

Abstract

To better understand the emergence of subtype C and its potential impact on vaccine efforts in Uganda, we have characterized subtype C sequences from Uganda (n = 13), Zimbabwe (n = 11), Mozambique (n = 5), South Africa (n = 4), and India (n = 3). Phylogenetic analysis of subtype C sequences in the env gp41 gene region revealed multiple subclusters within subtype C. Further, while most Ugandan specimen subclustered together, other subclusters did not reflect a clear geographic location. The nucleotide divergence within the Ugandan subset was 8.2% (6.1-9.8%) compared with 9.5% (2.5-15%) for the other subtype C gp41 sequences. The protein sequence alignment revealed marked sequence conservation of major immunodominant epitopes within the gp41 region.

Statistics

0200400'01'03'05'07'09'11'13'15'17
Citations per Year

301 Citations

Semantic Scholar estimates that this publication has 301 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Downing2000GeneticCA, title={Genetic characterization and phylogenetic analysis of HIV-1 subtype C from Uganda.}, author={Robert G. Downing and D . Pieniazek and Dale J. Hu and Benon Biryahwaho and Carol A. Fridlund and Mark A. Rayfield and Sylvester D K Sempala and Renu B. Lal}, journal={AIDS research and human retroviruses}, year={2000}, volume={16 8}, pages={815-9} }