Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.

@article{Buys2007GeneticCI,
  title={Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.},
  author={Timon P. H. Buys and Raj Chari and Eric H.L. Lee and May M Zhang and Calum MacAulay and Stephen Lam and Wan L. Lam and Victor Ling},
  journal={Genes, chromosomes & cancer},
  year={2007},
  volume={46 12},
  pages={1069-79}
}
The multidrug resistant (MDR) phenotype is often attributed to the activity of ATP-binding cassette (ABC) transporters such as P-glycoprotein (ABCB1). Previous work has suggested that modulation of MDR may not necessarily be a single gene trait. To identify factors that contribute to the emergence of MDR, we undertook integrative genomics analysis of the ovarian carcinoma cell line SKOV3 and a series of MDR derivatives of this line (SKVCRs). As resistance increased, comparative analysis of gene… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…