Genetic changes in breast cancer detected by comparative genomic hybridisation.

@article{Loveday2000GeneticCI,
  title={Genetic changes in breast cancer detected by comparative genomic hybridisation.},
  author={Ruth L Loveday and John Greenman and Deborah Simcox and Valerie Speirs and Philip John Drew and John R. T. Monson and Michael John Kerin},
  journal={International journal of cancer},
  year={2000},
  volume={86 4},
  pages={494-500}
}
Breast cancer is characterised by a number of genetic aberrations. Our purpose was to use comparative genomic hybridisation (CGH) to screen breast carcinomas for copy number changes: 44 ductal and 8 lobular carcinomas were studied and a large number of genetic aberrations identified. Many of these showed similarity to previous CGH results, however, a number of loci not previously shown to have undergone frequent change were identified. This included copy number gains affecting chromosomes 1p… CONTINUE READING