Genetic changes and telomerase activity in human renal cell carcinoma.

  title={Genetic changes and telomerase activity in human renal cell carcinoma.},
  author={Volker Rohde and H P Sattler and B Oehlenschl{\"a}ger and S Forster and T. B. H. Zwergel and Gerhardt Seitz and Bernd Wullich},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={4 1},
Using the sensitive telomeric repeat amplification protocol assay, we detected telomerase activity in 26 of 35 (74.3%) renal cell carcinomas analyzed. Subdivision of the tumors according to telomerase activity did not reveal an obvious association between the presence of telomerase activity and histomorphological stage, grade, tumor size, or DNA ploidy. Furthermore, no association was found between telomerase activity and a distinct chromosomal aberration pattern; namely, loss of genetic… CONTINUE READING


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