Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases--an analysis by comparative genomic hybridization.

@article{Jiang2005GeneticCA,
  title={Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases--an analysis by comparative genomic hybridization.},
  author={J K Jiang and Y Chen and Chi-Hung Lin and I Yu and J Lin},
  journal={Genes, chromosomes & cancer},
  year={2005},
  volume={43 1},
  pages={25-36}
}
About 10% of colorectal carcinoma patients develop pulmonary metastases during their lifetime. We address whether and how the chromosomal abnormalities differ between the primary cancers and their metastatic counterparts, what the clonality relationship (CR) is between them, and whether certain genomic aberrations contribute to this disease progression. Comparative genomic hybridization (CGH) experiments were performed on 18 paired samples of primary and pulmonary metastases obtained from… CONTINUE READING
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