Genetic causes of clopidogrel nonresponsiveness: which ones really count?

@article{Momary2010GeneticCO,
  title={Genetic causes of clopidogrel nonresponsiveness: which ones really count?},
  author={Kathryn M. Momary and Michael P. Dorsch and Eric R. Bates},
  journal={Pharmacotherapy},
  year={2010},
  volume={30 3},
  pages={265-74}
}
Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel responsiveness. Drug interactions with and genetic variation in CYP3A4, CYP3A5, and CYP2C19 enzymes have been implicated in decreasing active metabolite production. In addition… CONTINUE READING

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Cytochrome p-450 polymorphisms and response to clopidogrel.

The New England journal of medicine • 2009
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